Long-term erythropoietic repopulating ability of old, young, and fetal stem cells.
نویسندگان
چکیده
منابع مشابه
Long-term erythropoietic repopulating ability of old, young, and fetal stem cells
It is possible that erythropoietic stem cells do not age. This would mean that stem cells from old donors can function as well as those from young or fetal donors. The competitive repopulation assay has been used to test long-term stem cell function by directly comparing how well competing stem cells repopulate a recipient and produce differentiated cell types. C57BL/6J (B6) mice were used as d...
متن کاملUltimate erythropoietic repopulating abilities of fetal, young adult, and old adult cells compared using repeated irradiation
Erythropoietic repopulating abilities of fetal liver cells and young and old adult marrow cells were compared as follows: Equal numbers of cells from a donor of each age were mixed with a constant portion of cells pooled from genetically distinguishable competitors. These mixtures were transplanted into stem cell-depleted recipients, and the proportions of recipient hemoglobin that were donor t...
متن کاملStem cells with short-term and long-term repopulating ability in the mouse.
In the adult mouse the bone marrow serves as the major site for blood cell production and development. The large majority of the cells present in the bone marrow are relatively mature and derived from a small proportion designated as hematopoietic stem cells. These cells are capable of developing into all mature blood cell types and have the capacity of serf renewal. Hematopoietic stem cells re...
متن کاملIl-17 mobilizes peripheral blood stem cells with short- and long-term repopulating ability in mice.
Autologous and allogeneic bone marrow transplantations have evolved as important cancer therapy modalities. For both indications, peripheral blood has been shown to have distinct advantages over bone marrow as the stem cell source. Cytokine combinations for mobilization have enhanced stem cell yield and accelerated engraftment. However, novel mobilizing agents and strategies are needed to furth...
متن کاملLong-term repopulating ability of telomerase-deficient murine hematopoietic stem cells.
Telomere length must be tightly regulated in highly proliferative tissues, such as the lymphohematopoietic system. Under steady-state conditions, the levels and functionality of hematopoietic-committed or multipotent progenitors were not affected in late-generation telomerase-deficient mice (mTerc(-/-)) with critically short telomeres. Evaluation of self-renewal potential of mTerc(-/-) day-12 s...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1983
ISSN: 0022-1007,1540-9538
DOI: 10.1084/jem.157.5.1496